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Congenital Muscular Dystrophy Syndromes Distinguished by Alkaline and Acid Phosphatase, Merosin, & Dystrophin Staining Neurol 46:810-814, Connolly,A.M.,et al, 1996 See this aricle in Pubmed Article Abstract Congenital muscular dystrophy syndromes are characterized by congenital weakness,contractures,and dystrophic features on muscle biopsy.However, these syndromes are often difficult to diagnose precisely because their clinical and pathologic characteristics are not specific and resemble changes in other myopathies.We conclude that a pattern of few AcP-positive cells in the setting of numerous AlkP staining muscle fibers has specificity for congenital muscular dystrophy syndromes and provides histopathologic support for the diagnosis.Reduced merosin in muscle predicts more severe weakness and long-term disability.

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(click to filter results - removes previous filter) contractures,joint creatine phosphokinase(CPK)elevated developmental retardation disability,neurological dystrophin histochemistry histochemistry of muscle mental retardation merosin muscle biopsy muscle weakness muscular dystrophy muscular dystrophy,central nervous system abnormality muscular dystrophy,congenital prognosis weakness,congenital weakness,generalized

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